In general, an obvious association between PD-L1 rs17718883 SNP and lower cancer risk was discovered in all genetic models (G vs. C: OR = 0.07, 95% CI = 0.20-0.25, P = 0.000; GG vs. CC: OR = 0.04, 95% CI = 0.01-0.12, P = 0.000; GC vs. CC: OR = 0.07, 95% CI = 0.02-0.30, P = 0.000; GG+GC vs. CC: OR = 0.06, 95% CI = 0.02-0.24, P = 0.000; GG vs. GC+CC: OR = 0.06, 95% CI = 0.02-0.20, P = 0.000, Table 2). Here, CD274 is linked to cancer.