PDCD1 and colorectal carcinoma: However, the PD-1.3 variant evidently increased the risk of CRC (A vs. G: OR = 2.36, 95% CI = 1.54-3.61, P = 0.000; AA vs. GG: OR = 3.80, 95% CI = 1.77-8.18, P = 0.001; AA+GA vs. GG: OR = 2.60, 95% CI = 1.35-5.01, P = 0.004; AA vs. GG+GA: OR = 2.76, 95% CI = 1.44-5.27, P = 0.002).