CD274 and breast cancer: Results demonstrated that PD-L1 rs2890658 was dramatically correlated with the lower risk of HCC (C vs. A: OR = 0.74, 95% CI = 0.55-1.00, P = 0.046) and BC (C vs. A: OR = 0.53, 95% CI = 0.40-0.71, P = 0.000; CC vs. AA+CA: OR = 0.40, 95% CI = 0.28-0.57, P = 0.000), while the variant notably enhanced the risk of NSCLC (C vs. A: OR = 1.72, 95% CI = 1.39-2.13, P = 0.000; CA vs. AA: OR = 1.74, 95% CI = 1.37-2.19, P = 0.000).