LAMB3 and neoplasm: Moreover, when assessing the tumor-specific axes between AM and START that are affected by Unesbulin treatment, our interactome data support the hypothesis that ligands secreted by START, such as GAS6, COL4a1, and LAMB3, induce a protumor phenotype acquisition [tumor-associated macrophage (TAM) phenotype] in the macrophages that express their cognate receptors (Fig. 4K).