Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment was shown to be involved in some classical pathways, such as complement and coagulation cascade, Primary immunodeficiency, peroxisome proliferators-activated receptor (PPAP) signaling pathway, tumor necrosis factor (TNF) signaling pathway, and p53 signaling pathway (Figure 5B). The gene discussed is TNF; the disease is inborn error of immunity.