MAPT and neurodegenerative disease: In this context, an EBM called Subtype and Stage Inference (SuStaIn) capable of capturing spatio-temporal heterogeneity of diseases (Young et al., 2018) has been proposed to subtyping neurodegenerative diseases including typical AD and has been applied to find different spatio-temporal trajectories of longitudinal tau-PET data in AD (Vogel et al., 2021).