Moreover, based on the predicted results, we have explored the multifaceted etiology of CRS in CAR-T therapy from diverse perspectives and identified several overlooked cytokines, such as IFNG (IFN-γ), IFNA1, IFNB1, IFNA13, IFNA2, IFNAR1, IFNAR2, IFNGR1 and IFNGR2 that potentially play pivotal roles. Here, IFNGR2 is linked to congenital rubella syndrome.