In parallel, 7 genes (CXCL10, CXCL11, GBP1, IRF1, RARRES3, STAT1, TAP1) of the gray60 module play important dual roles in both immunoreaction and distant metastasis by activating either the epithelial‐mesenchymal transition pathway or T cell‐based immunosurveillance in several types of cancers.31, 32, 33. The gene discussed is IRF1; the disease is cancer.