Conflicting with the above, FTO downregulation was also reported in breast cancer, promoting tumour progression and metastasis via enhancing expression of mesenchymal markers including SNAI2, VIM, FN1, NT5E, SNAI1, MMP2 and ZEB1 while decreasing epithelial markers FSTL3, KRT18 and TJP1.87 The gene discussed is FTO; the disease is breast cancer.