Conflicting with the above, FTO downregulation was also reported in breast cancer, promoting tumour progression and metastasis via enhancing expression of mesenchymal markers including SNAI2, VIM, FN1, NT5E, SNAI1, MMP2 and ZEB1 while decreasing epithelial markers FSTL3, KRT18 and TJP1.87 This evidence concerns the gene FTO and neoplasm.