PTCH1 and Hepatic fibrosis: Specially, ALKBH5 can suppress hepatic stellate cell (HSC) activation and ameliorate liver fibrosis by triggering Patched 1 (PTCH1) activation and decreasing Dynamin-related protein 1 (Drp1) methylation in a m6A dependent fashion (Yang et al., 2022; Wang J. et al., 2023).