HIF1A and hepatocellular carcinoma: For instance, overexpressing METTL3 has been reported to induce glycolysis of HCC cells via induction of hepatitis B X-interacting protein (HBXIP) expression, enhancement of hypoxia-inducible factor-1 alpha (HIF-1α) level, as well as activation of mTORC1 signaling pathway (Lin Y. et al., 2020; Yang et al., 2021).