In diabetic nephropathy (DN), increasing urinary EV derived AFM, CP, and IGLV7-46 were upregulated with the DN progression, regucalcin protein was significantly downregulated in both urinary EVs and kidney tissue, while increasing C-megalin protein was predictive of the progression of the albuminuric stages (Zubiri et al., 2015; De et al., 2017; Du et al., 2023). Here, RGN is linked to liver dysplastic nodule.