Targeting has been shown to be positively correlated with tumor extracellular pH (Vavere et al., 2009; Macholl et al., 2012; Tapmeier et al., 2015), and it is enhanced by acidification using co-injection of glucose (Reshetnyak et al., 2011) or overexpression of CAIX (Tapmeier et al., 2015). Here, CA9 is linked to neoplasm.