The aim of this study was to determine the agreement between the PSMA-RADS and E-PSMA standardized reporting systems in the classification of [18F]PSMA-1007–uptaking lesions identified on PET/CT scans in patients with PCa and post-prostatectomy with suspected recurrent disease (local recurrence, regional nodal involvement and distant metastases), based on biochemical recurrence, while also exploring the correlation between lesion size and tracer uptake. Here, FOLH1 is linked to posterior cortical atrophy.