ESR2 and Alzheimer disease: The core nodes were screened by the mean values of degree, degree centrality (DC), closeness centrality (CC), betweenness centrality (BC) and other parameters, and finally nine key targets were obtained, including APP, NTRK1, ESR1, CFTR, CSNK2A1, EGFR, ESR2, GSK3B, and PAK1, which suggest that these targets play an important role in AS for AD.