ESR2 and Alzheimer disease: According to the statistical results of qRT-PCR (Figure 4A), the mRNA content expression of APP, NTRK1, ESR1, CFTR, CSNK2A1, EGFR, ESR2, GSK3B, and PAK1 in the hippocampus of the brains of mice in the AD group was significantly elevated compared with those of mice in the WT group (P< 0.01, P< 0.001, P< 0.0001).