For example, mAbs targeting the programmed death receptor axis PD-1/PD-L1, T cell immunoglobulin and ITIM domain (TIGIT), lymphocyte activation gene-3 (LAG-3), and T cell immunoglobulin mucin-3 (TIM-3) are known to enhance NK cell function and improve anti-tumor responses (40–43). The gene discussed is CD274; the disease is neoplasm.