In a recent transcriptomics study (196), genes upregulated in the renal tubules of patients with HTN were associated with IFN-γ, NF-κB, IL-12, and Wnt signaling pathways, all of which are involved in the inflammatory response, providing a broader perspective on the pathogenesis and treatment of human HTN. The gene discussed is NFKB1; the disease is hypertensive disorder.