Atorvastatin, a 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, can protect ischemic myocardium, inhibit cardiac remodeling, promote the recovery of cardiac autonomic nervous function, and thus protect cardiac function by downregulating the angiotensin-II (AngII) receptor.10,11 Recent studies have shown that atorvastatin not only improves the prognosis of cardiovascular disease patients and reduces the incidence of cardiovascular disease through its lipid-lowering effect, but also plays an antithrombotic, antioxidant, anti-inflammatory role. This evidence concerns the gene HMGCR and cardiovascular disorder.