TP53 and B-cell chronic lymphocytic leukemia: It has five independent variables, including TP53 and IGHV genes mutational status, age, clinical stage and β2M concentration, classifying patients into four risk categories (low, intermediate, high and very-high risk).8 For patients to be in very-high risk category, TP53 aberration should be present, highlighting importance of TP53 status in CLL.