The expression level of TPD52 in pancreatic cancer had no obvious correlation with the patient’s gender, age, tumor location, tumor diameter, lymph node metastasis, liver metastasis and portal vein invasion (P>0.05), but was obviously related to whether the tumor has extrapancreatic nerve invasion, tumor differentiation degree and TNM stage (P<0.05). The gene discussed is TPD52; the disease is neoplasm.