It was shown in this study that the expression level of TPD52 in cancer tissues of patients with pancreatic cancer was higher than that in normal paracancerous tissues, and the expression level of TPD52 in patients with extrapancreatic nerve invasion, low differentiation of tumor and late TNM stage was higher than that in patients without extrapancreatic nerve invasion, high differentiation of tumor and early TNM stage(P<0.05), suggesting high expression level of TPD52 in patients with pancreatic cancer with high malignancy and late disease, which was consistent with some research results. The gene discussed is TPD52; the disease is cancer.