Studies have shown that the most common biological functions of TPD52 are regulating extracellular secretion and vesicle transport, participating in tumor proliferation, invasion and metastasis, inhibiting tumor cell apoptosis and DNA repair, and being highly expressed in various tumor tissues, such as breast cancer, ovarian cancer and prostate cancer.12-14 Currently, the role of TPD52 in breast cancer and prostate cancer is the most widely studied, and it has also been studied in other malignant tumors. The gene discussed is TPD52; the disease is Familial prostate cancer.