According to allelic A vs. G, GA versus GG, and GA + AA versus GG inheritance models, TNF-rs1800629 is linked to an increased risk of sepsis, a systemic inflammatory response to infection [38], and also TNF-α-308 G > A (rs1800629) polymorphism may play an important role in the development of metabolic syndrome and A allele is a strong predictor in Egyptians. The gene discussed is TNF; the disease is metabolic syndrome.