CXCR2 and systemic inflammatory response syndrome: However, Yao et al. [39] who investigated the association of SNPs of the IL-8 gene rs4073 (-251T>A) and its receptor CXCR2 rs2230054 (+811T>C) with SIRS in patients exposed to wasp sting injury, observed significantly higher frequencies for the IL-8 - 251T allele (AT+TT) in the SIRS group when compared with the control group.