The aim of this study is to evaluate the association of TNFα -308 G>A (rs1800629), IL-8 -251T>A (rs4073), IL-10 (-1082 G>A), rs1800896, and CXCR2 +785 C>T (rs2230054) gene polymorphisms with the susceptibility and mortality of COVID-19, as limited studies have been reported from this part of the globe concerning this issue. This evidence concerns the gene TNF and COVID-19.