Significantly expressed in bladder cancer tissues compared to normal tissue. Reduces ROS production, rescues mitochondrial function, upregulates glutaminase levels, and increases GLS1 and GLS2 mRNA expression. Interferes with miR16's tumor suppressor role in bladder cancer cells. Regulates redox state and glutamine metabolism contributing to tumorigenesis. The gene discussed is GLS2; the disease is urinary bladder cancer.