Upregulated in RCC predominantly mediated by hypoxia-inducible factor1. Upregulated in blood serum of bladder cancer patients, increases with disease progression. Regulates bladder cancer growth, invasion, and metastasis by targeting FGFRL1. Overexpression is significantly higher in tumor tissues of prostate cancer, correlated with bone metastasis. The gene discussed is FGFRL1; the disease is Familial prostate cancer.