Several events have been associated with cigarette smoke condensate (CSC)-induced tumor progression in a recent study, including miR-30a downregulation and overexpression of binding immunoglobulin protein (BiP) as an endoplasmic reticulum (ER) stress regulator that enhances vascular endothelial growth factor (VEGF) production and secretionin OSCC cells both in vivo and in vitro [ 31 ]. This evidence concerns the gene HSPA5 and neoplasm.