KDM3A and Other metabolic disease: Previous studies have shown that mice lacking Jmjd1a exhibit obesity, and metabolic disorders, but these effects could be attributed to a combination of impaired BAT activation and scWAT beiging13,14,20 because both Jmjd1a-null mice and Jmjd1aSA/SA mice displayed defects in energy expenditure in both BAT and scWAT.