CDKN2A and pleomorphic xanthoastrocytoma: The contemporaneous presence of CDKN2A and/or CDKN2B homozygous deletion, detected in 90% of PXAs (Vaubel et al., 2021), and BRAF p.V600E mutation is highly suggestive (but not exclusive) of a PXA diagnosis (Nakajima et al., 2018).