This led to the identification of 63 Hypo‐Up genes that were both upregulated and hypomethylated in NSCLC tumor tissues compared with adjacent normal tissues, many of which such as ODC1,[31] BCL11A,[32] CDCA7,[33] and TRIM2[34] were shown to play important roles in the development and progression of NSCLC, while others 19 novel Hypo‐Up genes such as PCNX2, GOLGA7B, ZDHHC13, and MPP6 have not been reported in lung cancer. The gene discussed is PCNX2; the disease is lung cancer.