ZNF454 and neoplasm: It is noteworthy that the negative correlation between methylation of SETDB1 motifs and ZNF454 expression was also stronger in tumor samples (r = −0.66, p‐value = 4.8e‐08) compared to normal samples (r = −0.37, p‐value = 5.97e‐03) (Figure S9C, Supporting Information).