EXO1 and lung adenocarcinoma: Of note, there was a CpG site (cg12401425) in the motif3 contained in the Illumina Infinium HumanMethylation450 BeadChip.[44] Therefore, we analyzed Illumina methylation assays of lung adenocarcinoma (LUAD) and lung squamous cell caricinoma (LUSC) from TCGA, showing that the methylation of cg12401425 was significantly negatively associated with expression of EXO1 (Figure 6E,F).