ACHE and early-onset autosomal dominant Alzheimer disease: Acetylcholinesterase (AChE, E.C. 3.1.1.7) is an essential enzyme for the cleavage of acetylcholine in the nervous system and one of the most used enzymes in biosensors for pesticides (e.g., organophosphates and carbamates) and pharmaceuticals (e.g., a drug for Alzheimer’s disease treatment, donepezil) inhibiting cholinesterase [4,5].