There are several studies supporting the important role of T-cells in HIV infection control: (i) associations between specific human leukocyte antigen class I (HLA-I) alleles and relative control of infection [12,13,14], (ii) the presence of HIV mutations associated with certain HLA class I alleles referred to as HLA footprints [15,16,17,18], (iii) the emergence of HIV-specific CD8+ T-cells coinciding with viral set-point onset [19], and (iv) CD8+ T-cell depletion in animal studies that lead to the loss of viral control [4,20]. This evidence concerns the gene CD8A and HIV infectious disease.