CD44 and flatulence: The highly mucoid hyaluronic acid capsule induces the effective and smooth adherence of GAS pathogens in the pharynx, allowing it to bind to the surface glycoprotein CD44 of human epithelial cells, enhancing the colonisation and proliferation of GAS pathogens, resulting in invasive GAS infections and post-infections of GAS sequelae [18,52,56,57].