As a super-active protease with endopeptidase activity, SpeB contributes to the degradation of host extracellular matrix, immunoglobulins (IgG), complement components, GAS surface adhesins (including M protein and protein F1), multiple superantigens, leading to the escape of bacteria from immune clearance, invade the deeper tissue, and disseminate bacteria from the primary infection sites to host cells [79]. The gene discussed is MYOM2; the disease is infection.