Among these, the most frequently found to be increased in our review was TNF-α (58.3% in vitro, 59.1% in vivo, and 66.7% in human serum during the acute phase of infection), followed by IL-1β (66.7% in vitro, 38.6% in vivo, and 33.3% in human serum during the acute phase of infection) and IFN-γ (16.7% in vitro, 34.1% in vivo, 66.7% in human serum during the acute phase of infection, and 33.3% in human CSF during the acute phase of infection). This evidence concerns the gene TNF and infection.