It will be important to study additional effects of viral treatment, such as the effect on type I IFN signaling pathways; the effect on non-injected distant tumors; alterations in the expression of surface molecules, such as MHC-II, adhesion molecules, and PD-L1/PD-1 signaling, as well as studying specific responses according to the molecular profiles of the tumor such that the translatability of the results will be more accurate and including additional controls and a larger sample size to completely rule out any possible effect of the biopsy in the tumor immune response. The gene discussed is CD274; the disease is neoplasm.