F2 and chronic obstructive pulmonary disease: Overall, a total of eight canonical pathways were identified, which included the coagulation system, intrinsic prothrombin activation, extrinsic prothrombin activation, LXR/RXR activation, FXR/RXR activation, the neutrophil extracellular trap, acute-phase response signaling, and airway pathology in chronic obstructive pulmonary disease.