Based on these premises, it is not surprising that the systemic or local activity of ACE and ACE2 and the concentration of AngII and Ang1-7 have been described in many human tissues and organs, and over the years, their involvement in cardiovascular diseases (CVD), hypertension, type 2 diabetes, and chronic kidney disease has been gradually elucidated [12,13,14,15]. Here, ACE is linked to chronic kidney disease.