Decrease expression of TLR3, RIG-1, MDA5, and IRF3 was observed in cells pretreated with H2O2.Nrf2 siRNA showed decreased secretion of anti-viral interferons in transfected cells.Oxidative stress inhibiting the anti-viral interferons in the sinonasal mucosa due to RV infection is a potential road to prevent inflammation-induced PVOD. The gene discussed is TLR3; the disease is pulmonary venoocclusive disease.