A second cluster involved multiple markers of anemia (transferrin and serum iron), strongly associated with markers of one-carbon metabolism (B12, folate), liver metabolism (GGT, ALT, AST, LDH), ADP-ribosylation factors 1 and 3 (ARF1, ARF3), and the structural protein desmatin (DMTN). The gene discussed is TF; the disease is anemia (phenotype).