Further studies are warranted to include (a) in vitro assays for SNPs lacking functional data to clarify their impact on RIF PK and DILI mechanisms; (b) an analysis of other biomarkers to discriminate liver injury patterns and to speculate on liver injury primarily caused by RIF, as it may cause intrahepatic cholestasis in some patients; and (c) confirmation of the observed relationship between NR1I2 intronic polymorphism rs3732357 and RIF PK parameters in the other populations. The gene discussed is NR1I2; the disease is intrahepatic cholestasis.