PON1 and pancreatitis: However, the expected benefits of PON are partially counterbalanced in a third of patients by a broad spectrum of side effects, including high blood pressure, occlusive arterial and venous events, skin rash, myelosuppression, QTc prolongation, and pancreatitis, possibly related to pre-existing cardiovascular risk factors or to administered daily PON dose [16,17,18,19].