TRIM72 and Sepsis: circRTN4 effectively relieves cardiac injury and apoptosis, suppresses oxidative stress, and reduces inflammatory markers in sepsis-induced rats and lipopolysaccharide (LPS)-treated cardiomyocytes through its regulatory role in the miR-497-5p/MG53 pathway, where circRTN4 acts on miR-497-5p to upregulate MG53 which subsequently repairs damaged cell membranes [135,136].