NF1 and plexiform neurofibroma: Ranked from most AgNP-sensitive to least AgNP-sensitive are NF1-associated MPNSTs (NF1−/−); NF1-associated plexiform neurofibroma (NF1−/−); NF1-associated Schwann cells (NF1+/−); and Schwann cells (NF1+/+), which also corresponds to the increasing gene dose of functional neurofibromin.