CYBB and diabetic retinopathy: In the present study, we investigated the involvement of NOX2 isoform in pathologies associated with glutamate excitotoxicity and diabetic insults in the retina, by examining the neuroprotective and anti-inflammatory actions of the NOX2-specific inhibitor, GLX7013170, when administered intravitreally (AMPA excitotoxicity model) and topically as eye drops [early-stage diabetic retinopathy (ESDR) paradigm].