Prior studies, as well as work from our lab, have demonstrated chlorogenic acid (CGA) and cinnamaldehyde (CA) as two important plant-based bioactive agents with a strong ability to kill different types of breast cancer cells both alone and synergistically with other phytochemical agents by modifying the functions and structures of various cellular proteins and thus several pathways such as PI3K/Akt, MAPK, Nrf2, Wnt/β-catenin, p53 and NF-κB to cause cytotoxicity to breast cancer cells [11,12,13,14,15,16,17,18,19,20,21]. The gene discussed is NFKB1; the disease is breast carcinoma.