Surprisingly, the C1INH treatment was found to be inferior in the treatment of ACE inhibitor-induced angioedema compared to the placebo, specifically concerning the time to complete the resolution of symptoms (29.63 h ± 15.56 h in the C1INH arm and 17.29 h ± 10.40 h in the placebo arm) [76]. This evidence concerns the gene SERPING1 and angioedema.