18F-DOPA is a radiotracer that accumulates specifically in some PPGLs due to increased uptake by amino acid transporters: 18F-DOPA PET/CT represents the functional imaging of choice in cluster 1B and cluster 2 PPGLs, as well as in FH mutated and polycythemia-related PPGLs [11,21,32,36]. This evidence concerns the gene FH and polycythemia.