APP and Alzheimer disease: The extract also inhibited BACE-1 activities, decreased Aβ peptides, and improved locomotor function in a Drosophila model expressing human APP and BACE-1 representing the amyloid pathway, indicating promise for AD treatment.This study further elucidated the synergistic effects of D. esculentum and its identified phytochemicals, kaempferol, and quercetin with donepezil.