APP and Alzheimer disease: We previously reported that an ethanolic extract of D. esculentum (DE extract) significantly impacted AChE, BChE, and BACE-1 in vitro, suppressed BACE-1 activities and Aβ peptide formation, and improved locomotor functions of Drosophila expressing human APP and BACE-1 (an AD model of amyloidogenesis) [17].