NAT2 and liver disorder: Unfortunately, the hepatic NAT2 is polymorphic in humans, and the presence of mutations such as those detected in NAT2*7, NAT2*6 and NAT2*5 alleles can be associated with slow acetylation and the longer persistence of toxic metabolites [77]; this was evidenced in clinical studies enrolling patients with this metabolic condition and associated liver disease [78,79,80].