It is reported by Mu et al. [249] that in prostate cancer cells, TGF-β uses TRAF6, resulting in Lys63-linked polyubiquitination of TGF-βRI and promoting cleavage of the extracellular domain of TGF-βRI by TACE (TNF-alpha converting enzyme). The gene discussed is TGFB1; the disease is prostate cancer.