CDKN2A and ischemic stroke: Experimental evidence suggests that ischemic stroke triggers SASP, thereby releasing cellular factors, such as p16, p21, Il6, Tnfa, Cxcl1 and Cdk4, and chemokine receptor Cxcr-2 mRNA in the ipsilateral region penumbra as early at 30 min post middle cerebral artery occlusion (MCAO), and robust activation was observed 72 h post-MCAO [33].