The developed codelivery systems inhibited the proliferation of hepatocellular carcinoma (HCC) cells, induced in HepG2 cells apoptosis and the downregulation of two target genes of the miRNA, ADAM17 and Bcl-2, as well as greater anti-tumor efficacy in vivo (BALB/c nude mice) [15]. Here, ADAM17 is linked to hepatocellular carcinoma.