NLRP3 and colorectal carcinoma: Therefore, in this study, we investigated the effect of the P2X7 inhibitor, gli, as a blocking agent for assembling NLRP3 and the effect of miR-223 as a posttranslational inhibitor of NLRP3 in HCT-116 and HCT-15 CRC cell lines under NLRP3 activation.