ACE and acute kidney injury: We even find patients on triple whammy, the concomitant use of diuretics and angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (sartans) with NSAIDs, which per se is associated with high risk of acute renal failure [153], independent of the type of organ transplant or HSCT and further enhanced by CsA or TAC.