Researchers have found that a specific single nucleotide polymorphism in the TRPV4 gene, known as rs6606743, is markedly linked to the development of airway osmotic hyperresponsiveness in asthma patients with uncontrolled bronchial asthma, as compared to control patients who did not show any response to bronchoprovocation [54]. Here, TRPV4 is linked to asthma.