In the DiscovEHR human genetics study, loss-of-function variants in ANGPTL3 were found in 0.33% of case patients with CAD and in 0.45% of controls (adjusted OR 0.59, 95% CI 0.41 to 0.85, p = 0.004) [137]. This evidence concerns the gene ANGPTL3 and coronary artery disorder.