PTGS2 and obesity due to melanocortin 4 receptor deficiency: Numerous studies showed several biological properties including antioxidant and anti-inflammation, anti-insulin resistance, and anti-obesity of CGAs, caffeic acid, and also their derivatives through the reduction in iNOS and COX-2 expressions, and also diminished pro-inflammatory cytokine including IL-1β and TNF-α in LPS-induced RAW 264.7 macrophage [41,42,43,44,45].